Drugs and Chemicals to be Avoided in G6PD Deficiency

Drugs to be Avoided in G6PD Deficiency

There are different types of G6PD deficiency, an individual need to know the type of G6PD that they have inherited because each types of G6PD deficiency react to drugs differently and some may not react to some of the drugs and chemicals listed here. This is not a comprehensive list there are drugs and chemicals that may also be harmful to those with G6PD deficiency that are not on this list an individual should always consult their doctor for advice before taking any medication.

Generic NameTrade NameIndication
Acetanilide-Once used as analgesic/antipyretic
Methylene Blue-Methaemoglobinaemia
Naphthalene-Lavatory deodorant
Old fashioned mothballs
Nalidixic AcidMictralUrinary tract infection
Negram
Uriben
NidazoleAmbilharSchistosomicide
NitrofurantoinBerkfurinUrinary tract infection
Ceduran
Furadantin
Furan
Macrodantin
Urantoin
PamaquinePlasmoquineOnce used as an antimalarial
Pentaquine-Antimalarial
Primaquine-Antimalarial
SulphanilamideRhinamidNasal drops, vaginal cream
SulphacetamideAlbucidEye infections
Bleph-10 Liquifilm
Cortucid
Isoptocetamide
Minims
Ocusol
Sulfaped
Sulphacalyre
Sultrin Vaginal infections
SulphapyridineM & B 693Dermatitis, herpetiformis
Sulphamethoxazole Combination ProductsCo-Trimoxazole Urinary tract infections
Bactrin
Chemotrim
Comox
Contrimox
Fectrim
Laratrim
Septrin
ThiazosulphonePromizoleOnce used for leprosy

Drugs to be Used with Some Caution in G6PD Deficiency

A list of drugs is given in this section which might cause jaundice and anaemia in G6PD deficiency. Some of the drugs would do this if taken in too high doses; some could do so if taken for treatment of infections. If any of the drugs listed are being taken by patients it is important to check that the drug is not causing jaundice and anaemia.

As with the list of drugs known to provoke haemolysis, those in italics are available in the UK.

Generic NameTrade NameIndication
 
AcetaminophenParacetamolAnalgesic, antipyretic
        Combination Products
Calpol
Carisoma Co
Cosalgesic
Delimon
Dextrogesic
Dimotapp P
Distalgesic
Femerital
Fortagesic
Lobak
Medised
Migraleve
Myolgin
Norgesic
Paradeine
Paragesic
Paramax
Paramol
Parazolidin
Paxidal
Pharmidone
Pholcolix
Propain
Paedo-Sed
Paldesic
Pameton
Panadol
Panasorb
Rinurel (SA)
Safapryn (Co)
Salzone
Sudafed
Syndol
Tandalgesic
Triogesic
Tritussic
Uniflu
Veganin
        Combination with Caffeine
Cafadol
Panadeine Co
Paracodol
Parake
Medocene
Neurodyne
Unigesic
        Combination with Caffeine and Codeine
Parahypon
Paralgin
Pardale
Solpadeine
Acetophenetidine*PhenacetinAnalgesic, antipyretic
        
* This drug is now banned in the UK except by special prescription from a doctor or dentist
Amidopyrine, orAreumalAnalgesic, antiflammatory
AminopyrineBaukal
AminophenazoneBudirol
AminophenazoniumDepiral C
AmidazofenFenodone
Amidopyrine-PyramidonFever
Dimethylamino AntipyrineFtalazone
DimethylaminophenazoneGalenopyrine
Glucopirina
Hyparon
nst
Isoftal
Katareuma
Latepyrine
Metopirazone
Netsusarin
p-Aminobenzoic AcidTopical sunscreen agent
AnatazolineAntistin-PrivineNasal and eye drops for allergies
Otrivine Antisin
RBC
Vasocon-A
Ascorbic AcidThere is large numbers of pharmaceutical products containing ascorbic acid. These range from simple ascorbic acid tablets to multivitamin preparations. Unless large doses of ascorbic acid are taken it is unlikely that this substance will give rise to anaemia and jaundice.
AspirinAspergumAnalgesia
(Acetylsalicyclic Acid)Breoprin
Caprin
Claradin
Laboprin
Levius
Nu-Seals
Paynocil
Solprin
        Combination Products
Aspirin & Codeine
Aspirin & Papaveretum
Antoin
Codis
Dolasan
Doloxene
Equagesic
Hypon
Myolgin
Napsalgesic
Onadex-118
Robaxisal Forte
Safapryn
Trancoprin
Veganin
Zactirin
BenzhexolArtaneParkinsonism
Bentex
Benzhexol
Broflex
ChloramphenicolChloromycetinAntibiotic
Kemicetene
Sno-Phenicol
        Combination Products
Chloromycetin & Hydrocortisone
Tanderil Chloramphenicol
ChloroquineAvloclorAntimalarial
Malarivon
Nivaquine
DapsoneAvlosulfonLeprosy, dermatitis, herpetiformis
DADPS
Dapsone
D.A.P.S.
DDF
DDS
Diaphenylsulphone
Diphenason
Disulone
Disulphone
Dubronax
F1358
Novophone
NSC 6091
pp-Sulphodianiline
Sulphonyldianiline
Sulphon-mere
        Combination Products
Maloprim & Codeine
Sulphona Oral
Udolac
DiphenhydramineBenadrylAntihistamine
        Combination Products
Benafed
Benylin
Caladryl
Guanor
Histalix
Lotussin
Noradran
Pharmidone
Propain
Uniflu
IsoniazidRimiformAntituberculous
LevodopaBerkdopaParkinsonism
(L-Dopa)Brocadopa
Larodopa
Levodopa
Madopar
Sinemet
MenadioneMenaphthoneEssential for clotting of blood
Phytomenadione
Synavit
Konakion
Phenazone, orAuralgicinAnalgesic, topically in otitis media, antipyretic
AntipyrineAuraltone
PhenazoniumTaumasthman
Antipyrin
Azophenum
Alagesine
Penazona
PhenylbutazoneButacoteAnti- inflammatory agent
Butazolidin
Butazone
        Combination Products
ButazolidinAlka
Parazolidin
PhenytoinPhenytoinAnticonvulsant
Epanutin
        Combination Products
Garoin
ProbenecidBenemidUricosuria
ProcainamideDurulesArrythmia
Pronestyl
Nikartrone
Pyramidon
Pirasco
Piraseptolo
Piro Rectal
Piroreumal
P6BP
Pyrabitalum
Reubon
Reumanova
Reumasdina
Reumoftal
Reumo-Termina
Reumotrone
Revulex
Suppnon
ProguanilPaludrineAntimalarial
ChlorguanidePaludrinol
RP 3359
SN 12837
Proguanide
Chloroguanil
Chloruguane
PyrimethamineDaraprimAntimalarial
        Combination Products
Fansidar
Maloprim
QuinidineQuinidineArrythmia
Quinicardine
Kinidin
Kinitard
QuinineQuinineAntimalarial
StreptomycinStreptomycinAntibiotic
        Combination Products
Streptotriad
SulphacetamideSulphacetamideEye infections
Albucid
Bleph-10
Cortucid
Isoptocetamide
Ocusol
Sulfaped
Sulphacalyre
SultrinVaginal infections
Sulphacytine-Antibiotic
SulphamethoxypyridazineLederkynAntibiotic
Sulphanilamide
RP7522Aseptilex
AcetylAset-Sulfa
SulphamethoxypyridazineDurasul
Eusulfa
Exazol
Kemak
Kiron
Longusil
Metazina
Microcid
Midicel
Midikel
Minikel
Sulfadepot
Sulfadin
Sulfaitensa
Sulfalex
Sulfamizina
Sulfamyd
Sulfatar
Sulfa-Ultra
Sulforetent
Sulfo-Ridan
Sulforit
Sultrirene
Unisulfa
SulphapyridineM & B 693Dermatitis, herpetiformis
SulphadiazineSulphadiazineAntibiotic
        Combination Products
Streptotriad
Sulphtriad
SulphafurazoleGantrisinAntibiotic
Sulphisoxazole
SulphafurazSulfazole
SulphafurazolumUrogen
Novosoxazole
Sulfizole
Gantrisine
Panoid
Urazole
Gantrisona
Chemovag
Koro-Sulf
Lipo-Gantrisin
SK-Soxazole
Sosol
Soxa
Solfagun
Soxomide
Sulfalar
Sulfrizin
Urizole
Valmatrol
SulphaguanidineSulphaguanidineAntibiotic
        Combination Products
Guanimycin
Sulphamethoxazole-Urinary tract infections
        Combination Products
Co-trimoxazole
Bactrim
Chemotrim
Comox
Cotrimox
Fectrim
Laratrim
Septrin
TrimethoprimTrimethoprimAntibiotic
Ipral
Monotrim
Syraprim
Tiempe
Trimogal
Trimopan
        Combination Products
Bactrim
Chemotrim
Cofram
Comox
Cotrimox
Co-Trimoxazole
Laratrim
Polytrim
TripelennaminePyribenzamineAntihistamine
Sedilene
PBZ
Azaron

This is not a comprehensive list, there are drugs and chemicals that may also be harmful to those with G6PD deficiency that are not on this list, an individual with G6PD deficiency should always consult a doctor or pharmacist for advice before taking any medication.